Bidentate Ligands on Osmium(VI) Nitrido Complexes Control Intracellular Targeting and Cell Death Pathways #chempaperaday 262

Among the group 8 anticancer complexes, you see mostly ruthenium-based ones. But, this doesn't mean that ruthenium is unique or osmium doesn't work. In a series of posts, I'll focus on osmium complexes that show anticancer activities. Here is the first one. 

In this article, there are a series of osmium(VI) complexes and two of them show two different mechanism of action. And as the authors say one of them is "the first osmium compound to induce ER stress in cancer cells."

 http://pubs.acs.org/doi/abs/10.1021/ja4075375