Metal-based drugs that break the rules #chempaperaday 261

Since the accidental discovery of cisplatin's anticancer properties, people have tried to design platinum-based anticancer drugs. They did this mostly following the leading example of cisplation. Labile leaving groups, neutral compound, inert... More recently, people have been trying to break these "rules" and design and synthesize transition metal-anticancer complexes. Here in this article, you can read several examples of these compounds and the approach on their synthesis and purposes.

http://pubs.rsc.org/en/content/articlelanding/2016/dt/c5dt03919c#!divAbstract