This is a Perspective by H.B. Gray on hemoglobin and the beginning of bioinorganic chemistry. Below, you can
see the Gouy balance that Linus Pauling used when studying the magnetic
properties of hemoglobin and other related heme groups. I often do Evans method to
determine the number of unpaired electrons for some of my complexes and
believe me it is not the easiest thing to do. There are so many factors
that throws you off sometimes little sometimes really big. I find it
fascinating that with a Gouy balance they were able to calculate
solution magnetic moments very accurately. Today with all the advanced
instrumentation and techniques (X-ray, EXAFS, XANES, EPR etc.) there is
still debate on the bonding of O2 to the iron center. So, some of the
early work and theoretical explanations are still valid today!
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