Tuesday, April 1, 2014

42nd Annual James R. Killian Jr. Faculty Achievement Award Lecture:Understanding and Improving Platinum Anticancer Drugs

If you have been following the blog for some time (or if you actually know me), you must know that I am also interested in metal based anticancer drugs. Today I attended Stephen Lippard's award lecture at MIT where he gave a talk about platinum anticancer drugs for 1.5 hours.

Here is the recognition for his work and award:

Stephen J. Lippard, who is widely acknowledged as one of the founders of the field of bioinorganic chemistry, is this year's recipient of MIT's James R. Killian Jr. Faculty Achievement Award.
Established in 1971 to honor MIT's 10th president, the Killian Award recognizes extraordinary professional achievements by an MIT faculty member.

In announcing this year's award at the May 15 faculty meeting, the award committee noted that Lippard's groundbreaking work has pushed back the frontiers of inorganic chemistry, while simultaneously paving the way for improvements in human health and the conquering of disease.

Lippard, the Arthur Amos Noyes Professor of Chemistry, has spent his career studying the role of inorganic molecules, especially metal ions and their complexes, in critical processes of biological systems. He has made pioneering contributions in understanding the mechanism of the cancer drug cisplatin and in designing new variants to combat drug resistance and side effects.

His research achievements include the preparation of synthetic models for metalloproteins; structural and mechanistic studies of iron-containing bacterial monooxygenases including soluble methane monooxygenase; and the invention of probes to elucidate the roles of mobile zinc and nitric oxide in biological signaling and disease. 
 Especially, he focused on one of his recent projects : Osmium complexes. I also think that he is equally interested in Pt(IV) complexes. It was great to see and listen to him again after ACS Dallas national meeting.

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