I read this paper by Lewis Wolpert today. I think it was a talk that he gave and this is the transcript. Anyway, you can agree with him or not, it is up to you. But, I think there are really important points in his speech. I try to stay away from "controversial: issues. So, I won't comment on what parts I agree with him and what parts I don't. It is worth reading.
You can read it free here: