Saturday, April 4, 2015

Michele Peyrone, Discoverer of Cisplatin #chempaperaday 205

Cisplatin is a very effective anticancer drug especially against testicular cancer. It is also probably one of the most important metal complexes that opened a new research area for developing anticancer drugs. Its biological activity was discovered accidentally by Barnett Rosenberg and colleagues and it was approved by FDA in a very short time compared to any other drugs. 

Anytime you read a biochemistry or bioinorganic chemistry paper about metal anticancer complexes (covalent ones especially), you can read a very similar introduction. But, some of them also mention that the complex was synthesized almost 100 years prior to its "fame". Cisplatin was first synthesized by Michele Peyrone in 1844. Knowing nothing about isomerism of course, Peyrone described the physical properties of the compound and hypothesized its forming. It was then named as Peyrone's  Chloride.  I found it very interesting that Peyrone worked under Justus von Liebig. Later, Peyrone focused on agricultural chemistry and did not pursue his studies on platinum compounds.

The article is written by four authors and the name George B. Kauffman caught my attention of course. I know his writings very well and try to read as many as possible

It was good to know Michele Peyrone closer and I suggest you do the same.

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