Among the metal based anticancer complexes, third row metal-based ones are the most common. In fact, Pt-based ones like cisplatin, carboplatin, oxaliplatin are really effective anticancer drugs. In this article, the authors summarize the mechanism of "classical" Pt-based anticancer complexes and briefly talk about the new "monofunctional" complexes (pyriplatin, phenanthriplatin). These are Pt complexes with a net + charge and they are trying to exploit the organic cation transporters. Finally, there are a few examples of really active Os(VI) based complexes.