Thursday, September 24, 2015

Cellular interactions of platinum drugs #chempaperaday 232

This is a 2012 review paper and a really good summary on the fate of platinum drugs in model systems and in cells. 

While we know that cisplatin completely cures testicular cancer and is very effective in a few other cancer types, the mechanism of action is still not really known. It is also not known why it is so selective against testicular cancer. The article made me really realize how little we know about cisplatin and other platinum anticancer drugs. There are tens of cellular targets and it is still not understood what happens to cisplatin when it enters the cell. In fact, only 1% of cisplatin ends up binding to DNA. There is still so much work to do to answer these questions and develop better drugs. I hope I can help one day.

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