#chempaperaday Day 29/365: "Biosynthesis of the Urease Metallocenter"

I am dying to know how metalloproteins are "made" and folded in the cell. When do the metals take their places? How is the concentration of the metal ion is regulated? What kind of proteins or molecules helped them to enter the cell and how do they end up where they belong?

This article is a review about urease; a nickel containing metalloprotein.

http://www.jbc.org/content/288/19/13178

http://www.rcsb.org/pdb/explore/explore.do?structureId=1FWJ