Monday, February 17, 2014

#chempaperaday Day 31/365: "A platinum complex that binds non-covalently to DNA and induces cell death via a different mechanism than cisplatin"

This article is an open access article about a Pt(II) terpyridine complex and its interaction and binding mode with DNA. 

The studies showed that the complex can enter the cell nucleus and interact with DNA in a non-covalent manner. They also found that the complex has a selective cytotoxicity towards certain cancer lines.

I have been trying to follow metal complex-DNA interaction papers. But, looks like I missed this one. It's a great study. But, I would like to know why there is no x-ray data.

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